It was developed from the traditional formula “Zhen-Wu-Tang.” Qishen granules protect against ER stress-induced myocardial apoptosis via the inositol-requiring enzyme 1 (IRE1)–alpha B-Crystallin (CRYAB) pathway, which is a promising therapeutic target for myocardial ischemia [162]. This evidence concerns the gene CRYAB and myocardial ischemia.