Recent studies have shown that ATIC-associated DNPS are strongly associated with cancer cell proliferation [3,4,5], that defective ATIC function leads to neurodevelopmental disorders and aortic stenosis [6], and that ATIC promotes pulmonary artery smooth muscle cell proliferation in pulmonary vascular remodeling through the Ras signaling pathway [7]. The gene discussed is ATIC; the disease is aortic stenosis.