IGFBP2 and pulmonary fibrosis: IGFBP-2 transgenic mice have reduced senescence in alveolar epithelial type 2 (AEC2) cells and have reduced bleomycin-induced lung fibrosis; moreover, recombinant IGFBP-2 is anti-fibrotic in bleomycin lung fibrosis, and IGFBP-2 expression is decreased in AEC2 cells isolated from fibrotic lung regions of patients with IPF.