IGFBP7 and scleroderma: IGFBP-7-induced senescence is exhibited in the progression of diseases such as scleroderma, in which human dermal fibroblasts cultured with both IGFBP-7 and TGF-β1 upregulated the expression of genes associated with myofibroblast differentiation and cellular senescence compared to healthy control fibroblasts [26].