INS and neoplasm: What is inferred. The same integrin FAK–RhoA/actomyosin→YAP/TAZ–TEAD mechanotransduction network that senses matrix stiffness in PDAC stromal/tumour cells [74,75,76,77] may alter β-cell mechanosensing at the capillary/ECM interface of islets, where integrin–FAK signalling focuses insulin release [78,79,80].