Beyond NF-κB and COX-2 modulation, pecan kernel constituents influence additional inflammatory pathways relevant to cancer biology, including the mitogen-activated protein kinase (MAPK) cascades, signal transducer and activator of transcription 3 (STAT3), and the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome. The gene discussed is STAT3; the disease is cancer.