In another study, Song and co-workers designed and synthesized ROS-responsive monomeric and dimeric thiol adducts of scaberol C (122), a germacrane SL, [76] and examined the activity of those pro-drugs for TrxR1 (thioredoxin reductase 1) inhibitory activity and their impact against non-small cell lung cancer (NSCLC) cell lines, including H1299, A549, and H460 (Scheme 6). This evidence concerns the gene TXNRD1 and non-small cell lung carcinoma.