HCT116 cells were treated with 1 μM of each TBM because previously 1 μM of compound 5 (Figure S5) and 1 μM of quercetin (Figure 1D) were shown to decrease MALAT1 levels by ~50% in the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) tumor organoid model and MCF7 breast cancer cell lines, respectively [16,20]. Here, MALAT1 is linked to breast cancer.