Selective inhibitors of various kinases, including cyclin-dependent kinases 4 and 6 (CDK4/6), epidermal growth factor receptor (EGFR) tyrosine kinase, and aurora kinase A have shown promise in various malignancies by inhibiting cell cycle progression and suppressing the growth of 3D tumor spheroids [28,29,30]. The gene discussed is EGFR; the disease is neoplasm.