Previously, the sodium salt of 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1S) and its analogs demonstrated a high-affinity JNK inhibition in nanomolar range (Kd from 90 to 390 nM toward JNK1-3 isoforms) as well as the inhibition of transcription factors nuclear factor κB (NF-κB) and activator protein 1 (AP-1) activation in human cells of monocytic leukemia [34,35,36]. This evidence concerns the gene JUN and monocytic leukemia.