TNF and breast cancer: Domínguez-Martín et al. (2020) [100] report in their work that an aqueous extract of C. aspersum garden snail has antitumor effects on the necrosis-inducing breast cancer H5578T cell line; in addition, it is a potent stimulator of TNF-α and an inhibitor of NF-κβ, PTEN, and p53 factors that regulate tumor development.