Within lung cancer—predominantly NSCLC (e.g., A549, H1299, H460, H2170)—coumarin scaffolds have been investigated as modulators of EMT/motility, topoisomerase I and CDK2 activity, Hsp90 chaperone function, and the PI3K/Akt/mTOR pathway, with coordinated effects on apoptosis and autophagy. Here, CDK2 is linked to non-small cell lung carcinoma.