These include HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase), a key enzyme in cholesterol biosynthesis and a potential mediator at the lipid–carbohydrate interface [19]; FABP4 (fatty acid-binding protein 4), whose increased expression has been observed in hepatocytes in both alcoholic and non-alcoholic steatohepatitis [20]; and LIPG (endothelial lipase), involved in lipoprotein hydrolysis and a translational candidate in obesity prevention [21]. Here, HMGCR is linked to obesity due to melanocortin 4 receptor deficiency.