The main causes of hypoglycemia can be classified into endocrine (including hyperinsulinism, growth hormone deficiency, cortisol deficiency, and increased Insulin-Like Growth Factor-II secretion during Wilms’ tumor, nephroblastoma, dysgerminomas, and lymphomas/leukemias) or metabolic etiology (Figure 1) [69,70]. This evidence concerns the gene IGF2 and Nephroblastoma.