Additionally, interference with the TCF11 and MafG motifs could disrupt heterodimeric regulation of proteasomal and stress-response genes, contributing to proteotoxic stress in T2D, as TCF11 plays a tumor-suppressive role in proteostasis and MafG, via its lncRNA axis, influences glucose metabolism [35,36]. Here, MAFG is linked to type 2 diabetes mellitus.