The obtained VCAM-1 and transferrin serum measurements in this preliminary single center study suggest that tauopathic Parkinsonisms are likely to differ when compared with controls; however, their significance in the differentiation of PSP-P, PSP-RS, and CBS seems barely pronounced, as the only significant difference was observed between PSP-P and CBS in serum transferrin. This evidence concerns the gene VCAM1 and Parkinson disease.