The optimal cut-off value of the CRP for discriminating sepsis from NIOF was 36.95 mg/L (AUC, 0.843; 95% CI, 0.814–0.873; sensitivity, 81.1%; specificity, 78.9%; p < 0.001), and that for discriminating septic shock from sepsis was 227.35 mg/L (AUC, 0.559; 95% CI, 0.505–0.613; sensitivity, 23.3%; specificity, 89.1%; p = 0.032), respectively. This evidence concerns the gene CRP and Sepsis.