In the ROC curve analysis, the AUC of the combination of 3 biomarkers (Gal-9, sTREM-1, sCD25) was 0.670 (95% confidence interval [CI], 0.615–0.726; p < 0.001), and the model was well calibrated (Hosmer-Lemeshow test; Χ2 = 5.530; df = 8; p = 0.700) for predicting 30-day mortality in patients with sepsis and septic shock. Here, LGALS9 is linked to Sepsis.