GLP1R and diabetes mellitus: Silibinin, another potential chemical component, increased the expression of glucagon-like peptide-1 receptor (GLP1R) in the duodenum, and the activation of neurons in the nucleus of the solitary tract decreased hepatic glucose production at 100–300 mg/kg in rats when fed with a high-fat diet, alongside alleviating streptozotocin-induced diabetes [60].