We employed a novel analytical method to map cognitive resilience as a continuously varying quantitative trait in AD‐BXD strains, and using computational genomics, nine pQTL‐identified proteins were found to be significantly associated with cognitive resilience, with eight (Akr1a1, Gars1, Iars2, Nudt3, Ogdh, Ppt1, Ptpn1, and Uba1) located within a shared haplotype block region on chromosome 1. This evidence concerns the gene AKR1A1 and Alzheimer disease.