NR1D1 and early-onset autosomal dominant Alzheimer disease: Notably, human studies indicate that there are local regulatory variants (eQTL) controlling the expression of NR1D1 mRNA and that NR1D1 mRNA expression is altered in the dorsolateral prefrontal cortex (DLPFC) of AD patients (https://agora.adknowledgeportal.org/genes/ENSG00000126368/evidence/rna; Accelerating Medicines Partnership ‐ Alzheimer's Disease (AMP‐AD) consortium).69