We found that high-concentration Shengjiang San treatment significantly increased the p-AMPK/AMPK ratio in the liver, while decreasing the p-mTOR/mTOR ratio and the expression levels of inflammatory factors (IL-6, TNF-α), indicating that Shengjiang San inhibits oxidative stress and inflammation through the AMPK/mTOR pathway, thereby exerting a beneficial effect on fatty liver. The gene discussed is TNF; the disease is fatty liver disease.