These observations are directionally consistent with prior work in C57BL/6J cohorts showing that Septin5+/− and Septin5−/− mice—as well as mice with region-specific overexpression in the dorsal hippocampus or amygdala—showed no discernible differences relative to Septin5+/+ mice in motor or anxiety-related behaviors on the open field and elevated plus maze tests [9], and with findings that Septin5−/− mice did not alter startle behavior on mixed and 129-enriched backgrounds [8]. The gene discussed is SEPTIN5; the disease is Anxiety.