HAVCR2 and neoplasm: Additionally, a flow cytometric analysis revealed that the status of CD8+ tumor-infiltrating lymphocytes (TILs) ranged from young, multifunctional populations (T cell factor 1 (Tcf-1)+ Thymocyte selection-associated high mobility group box (TOX)− Programmed death-1 (PD-1)int T-cell immunoglobulin and mucin-domain containing-3 (Tim3)−) to highly cytotoxic activated states (PD-1+Tim3− Granzyme B (GzmB)+IFN-γ+), and ultimately to an exhausted state (Tcf-1−TOX+PD-1+Tim3+).