These included IL1R1 (hypermethylated among lean), FMNL2 (hypermethylated in obesity) in OVAT (Table 3, Fig. 6C) and TSC22D1 (hypermethylated in obesity) in SAT (Table 3, Fig. 6D). The gene discussed is FMNL2; the disease is obesity due to melanocortin 4 receptor deficiency.