The obesity specific DMRs from OVAT investigated in more detail include Interleukin 1 Receptor 1 (IL1R1), BRCA2 and CDKN1A Interacting Protein (BCCIP) and Formin Like 2 (FMNL2). Interestingly, we show that obesity specific methylation of IL1R1 in OVAT correlates with clinical features of glucose metabolism such as serum triglycerides and HbA1c, and that m6A at this target promotes RNA decay in OVAT. Here, IL1R1 is linked to obesity due to melanocortin 4 receptor deficiency.