Further, we investigated in more detail selected DMRs in TSC22D1, HAS2, GCC1, NCKIPSD from SAT, all being hypermethylated in individuals with obesity and BCCIP, IL1R1 (hypermethylated in lean) and FMNL2 (hypermethylated in individuals with obesity) from OVAT (Table 3). The gene discussed is NCKIPSD; the disease is obesity due to melanocortin 4 receptor deficiency.