Further, we investigated in more detail selected DMRs in TSC22D1, HAS2, GCC1, NCKIPSD from SAT, all being hypermethylated in individuals with obesity and BCCIP, IL1R1 (hypermethylated in lean) and FMNL2 (hypermethylated in individuals with obesity) from OVAT (Table 3). This evidence concerns the gene IL1R1 and obesity due to melanocortin 4 receptor deficiency.