ARHGAP6 is to our knowledge not yet linked to a specific mechanism related to obesity or metabolic disease; however it was shown to be differentially DNA methylated in adipocytes in obese mice [39], and was reported to be involved in regulation of glucose metabolism, cell proliferation and migration by regulating STAT3 signalling in cancer [40]. The gene discussed is STAT3; the disease is obesity due to melanocortin 4 receptor deficiency.