Examples of targets with differential methylation in SAT between individuals with obesity and lean counterparts include Transforming Growth Factor β 1-stimulated Clone 22 D1 (TSC22D1), Hyaluronan Synthase 2 (HAS2), GRIP And Coiled-Coil Domain Containing 1 (GCC1) and NCK Interacting Protein With SH3 Domain (NCKIPSD). This evidence concerns the gene TSC22D1 and obesity due to melanocortin 4 receptor deficiency.