These included IL1R1 (hypermethylated among lean), FMNL2 (hypermethylated in obesity) in OVAT (Table 3, Fig. 6C) and TSC22D1 (hypermethylated in obesity) in SAT (Table 3, Fig. 6D). This evidence concerns the gene IL1R1 and obesity due to melanocortin 4 receptor deficiency.