Mechanically, pyroptosis-mediated by GSDME in cardiomyocytes facilitates ICIs-associated myocarditis via mediating mitochondrial damage and releasing mitochondrial DNA (mtDNA), further activating cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway [33]. The gene discussed is GSDME; the disease is myocarditis.