After the two year follow-up, based on clinical manifestations, C-peptide levels, insulin treatment dependency, and other factors during follow-up, the final classification are as follows: there were 113 individuals with diabetes maintaining their initial diagnosis, with 67 (93.06%) diagnosed with T1DM and 46 (100.0%) diagnosed with T2DM. The gene discussed is INS; the disease is type 2 diabetes mellitus.