Given that PD-L1 expression is regulated by complex transcriptional and post-translational mechanisms—including glycosylation, ubiquitination, phosphorylation, and acetylation—across various cancers [37], it is plausible that KAT2A may promote PD-L1 transcription by modulating histone acetylation at its promoter or enhancer regions. This evidence concerns the gene KAT2A and cancer.