Additionally, the polymorphism rs4986790 (−896 A/G, Asp299Gly) in TLR4 was associated with GCA susceptibility in a Spanish cohort of biopsy-positive GCA patients (Palomino-Morales et al. 2009), although no association with ischemic symptoms was found in another study (Alvarez Rodriguez et al. 2011). This evidence concerns the gene TLR4 and temporal arteritis.