Considering the increased expression of innate immunity mediators in TABs, and the inhibitory effect on IL-6 production exerted by GC and 5Z-7-oxozeanol in fibrinogen- or SAA-treated immune cells, we speculate about the potential therapeutic effect of TLR antagonists (such as hydroxychloroquine for TLR7) to reduce the inflammation in GCA. The gene discussed is TLR7; the disease is temporal arteritis.