Here, starting from simple single-input RNA sensors, a community of Eterna citizen scientists successfully designed more complex multi-input RNA sensors, including all possible logic gate sensors, two-input ratio sensors and, in the OpenTB challenge, sensors of the three-gene TB-score [GBP5][DUSP3]/[KLF2]2 for diagnosing active TB. This evidence concerns the gene KLF2 and tuberculosis.