HES1 and breast cancer: The 3406 differentially expressed transcripts included a Notch signaling signature (high DLL1, HES1, and DTX3, low DLL3), as well as transcripts linked to estrogen signaling (TFF1, AHR), luminal B breast cancers (POTED), VEGFA, EGFR, BRAF, TGFB1, and several cytokines (e.g., IL17, IL12B, IL21, IL18).