This was supported by immunofluorescence analysis that indicated expression of the basal keratinocyte marker KRT14 (K14) in both basal layer of mouse skin and mouse tumors, while the differentiation marker KRT10 (K10) was only detected in mouse skin, hair follicles, tumor from WT mice, but not in the tumor from DF2 cKO mice (Supplementary Fig. S17C). The gene discussed is KRT14; the disease is neoplasm.