Therefore, disruptionin the regulation of these adhesion molecules has been implicatedin the onset and progression of various inflammatory diseases, wherecompromised epithelial barriers facilitate microbial invasion andperpetuate chronic inflammation.,,, Immunofluorescenceanalyses further confirmed that E-cadherin and ZO-1 were either weaklyexpressed or absent in peri-implantitis tissues. This evidence concerns the gene TJP1 and inflammatory response.