CD8A and type 1 diabetes mellitus: Furthermore, despite our inability to examine in detail immune infiltration around small EOs in human T1D pancreas, due to their virtual absence, the evidence of elevated acinar inflammation in individuals with T1D, and the presence of islet-reactive CD8+ T cells in the exocrine compartment, supports the presence of an immune component capable of targeting β cells in the extraislet environment (59–61).