Notably, by inspecting the distal, intronic, and promoter chromatin regions and their linked regulatory target genes, we identified changes containing AD and FTD genetic risk loci, including TMEM106B, ADAM10, SORL1, KAT8, CLU, BIN1, and genes involved in essential cellular activity, such as UBE3A. Here, UBE3A is linked to frontotemporal dementia.