Besides GLDN, in our snRNA-seq analyses, some of the AD GWAS genes, such as ADAM10, ADAM17, BIN1, APP, CLU, JAZF1, MAPT, PICALM, PLEKHA1, SLC24A4, SORL1, and UMAD1, were also differentially expressed in PiD (table S4, A and B). This evidence concerns the gene PICALM and Alzheimer disease.