MTA2 and Alzheimer disease: We processed our single-nucleus data separately in PiD from our previously generated snATAC-seq data of AD (10x Genomics; n = 12 late-stage AD, n = 8 control) (17) and snRNA-seq (10x Genomics; n = 11 late-stage AD, n = 7 control) (Fig. 1A) (17, 28).