At the same time, we identified hypoxia-inducible factor-1α (HIF1A), regulated by both JUND and BACH1, as down-regulated in PiD (FDR-adjusted P = 4.35 × 10−6; table S4A) but not statistically significant in AD, which may align with previous reports suggesting that the loss of HIF1A within astrocytes protects neurons from cell death (78). This evidence concerns the gene JUND and Alzheimer disease.