We identified differential binding activities of TFs, such as SPI1, known as a major AD GWAS risk gene in microglia and associated with its development, JUND in astrocytes, known for its strong correlations with pTau and Aβ, and transcriptional suppressors HES1 and ZBTB33 in oligodendrocytes, shedding light on their potential roles in disease pathogenesis. Here, SPI1 is linked to Alzheimer disease.