SIRT1 and steatosis: More, treadmill exercise enhanced the expression of PPARα and SIRT1, thereby affecting the downstream hepatic steatosis-associated target genes, including CPT1(Carnitine palmitoyltransferase 1), CPT2(Carnitine palmitoyltransferase 2), SLC27A1(Solute carrier family 27 member 1), SLC27A4(Solute carrier family 27 member 4), in addition to activating the expression of the central metabolic sensor AMPK.