Besides, studies have reported that inhibition of miR-34a may increase the levels of its downstream targets, including peroxisome proliferator-activated receptor-α (PPARα) and Sirtuin protein family-Sirtuin1 (SIRT1) that were related to fatty acid oxidation thereby alleviating liver steatosis [10]. The gene discussed is SIRT1; the disease is Hepatic steatosis.