MYD88 and Mental deterioration: Patients at risk for postoperative cognitive decline exhibit dampened phosphorylated cyclic adenosine monophosphate response–element binding protein response in adaptive cells to exogenous stress, this indicates that prehabilitation may mitigate postoperative cognitive decline risk after surgery.35 Interestingly, dampened MyD88 response to exogenous stress is a hallmark of immunosenescence,50,51 a dynamic and multifactorial process affecting both innate and adaptive immune cells.