CNS complications in DOCK8 deficiency may include both infectious (e.g., meningitis, encephalitis) and non-infectious manifestations (e.g., vasculitis, aneurysms, stroke, and brain and optic atrophy), with the latter reflecting a broader neuroinflammatory and vascular vulnerability independent of infection (Engelhardt et al. 2009; Zhang et al. 2009; Aydin et al. 2015). This evidence concerns the gene DOCK8 and hyperinsulinemic hypoglycemia, familial, 4.