During ischemia, PDGF-BB stimulation induced QKI-6, promoting HDAC7 splicing, activation of SM22, and iPS-VSMC differentiation, thus demonstrating QKI-6 is critical for the modulation of HDAC7 splicing for regulating iPS-VSMCs differentiation and functionality [33, 64]. The gene discussed is HDAC7; the disease is ischemia.