MMP2 and myopia: Given that MC degranulation has been implicated in fibroblast activation and fibroblast-to-myofibroblast transdifferentiation by increasing MMP-2 activity,31,32 and considering that enhanced myofibroblast differentiation in the sclera is one of the hallmarks of myopia,33 our results strongly support the notion that limbal MCs contribute directly to scleral remodeling during myopia development.