INS and metabolic dysfunction-associated steatotic liver disease: According to WikiPathways (WP),16 the LEPR gene is included in several pathways: Leptin and adiponectin (WP3934), Leptin Insulin Overlap (WP3935), Nonalcoholic fatty liver disease (WP4396), Leptin signaling pathway (WP2034), and the AMP-activated protein kinase (AMPK) signaling pathway (WP1403).