BC cases with clinical stage T II and positive LN, as well as tumor histologic grade III, presence of obesity, pre-diabetic events, DM, or IR, were associated with CD295 rs6700986 mutant homozygous (CC) and heterozygous (CT) genotypes and ITLN1 rs952804 mutant CT genotype (p ≤ 0.05). This evidence concerns the gene LEPR and breast cancer.