MAPT and early-onset autosomal dominant Alzheimer disease: Some examples of IDPs in disease are Amyloid-beta, which is a key protein involved in Alzheimer’s disease, Tau protein, which is also implicated in Alzheimer’s and other neurodegenerative disorders, α-Synuclein, a protein associated with Parkinson’s disease and Lewy body dementia, and p53 and BRCA1 associated with cancer [116].