MAPT and Alzheimer disease: On the contrary, prolonged exposure to continuous electromagnetic pulse at 100 Hz and a very high electric field (50 kV/m), for 8 months in Sprague Dawley led to cognitive and memory impairment, increased Aβ level, increased expression of Aβ oligomer and APP, and increased expression of Tau, suggesting a continuous high electric field exposure can cause harmful effects and increase AD pathology [200].