Similarly, the GUIDE-IT trial demonstrated that a higher frailty (frailty index criteria) burden was associated with a significantly higher risk of HF hospitalization or death [HR: 1.76, 95% CI: 1.20–2.58], adjusted for LVEF, NYHA class, NT-proBNP and etc. (26). The gene discussed is NPPB; the disease is hydrops fetalis.