Studies from South Africa leveraging the racial diversity of South Africa have explored the utility of PSMA PET imaging to interrogate the racial differences in tumor phenotype at staging and restaging of prostate cancer.52, 53While subtle differences exist in the prostate cancer seen in White versus Black South Africans, especially at the time of initial disease diagnosis, the implication of these differences in response to treatment in general and response to PSMA radioligand therapy remains unexplored currently. The gene discussed is FOLH1; the disease is neoplasm.