Studies from India and China have contributed to the emerging body of literature demonstrating the utility of PSMA PET/CT to guide biopsy for improved detection of csPCa.47, 48, 49In the study by Zhang et al, PSMA PET-guided prostate biopsy had a higher yield for csPCa than transrectal ultrasound-guided biopsy.48PSMA expression level is proportional to tumor aggressiveness. This evidence concerns the gene FOLH1 and neoplasm.