225Ac-DOTA-Anti-CD38 daratumumab monoclonal antibody with fludarabine, melphalan, and total marrow and lymphoid irradiation as a conditioning treatment for donor stem cell transplant in patients with high-risk acute myeloid leukemia, acute lymphoblastic leukemia, and myelodysplastic syndrome. Here, CD38 is linked to acute myeloid leukemia.