MEG3 and esophageal squamous cell carcinoma: In esophageal squamous cell carcinoma (ESCC), lncRNA MEG3 indirectly upregulates FOXP3 expression by inhibiting the ubiquitination of p53, an upstream regulator of miR-149-3p, thereby enhancing the immunosuppressive activity of Tregs (Xu et al., 2021).