In esophageal squamous cell carcinoma (ESCC), lncRNA MEG3 indirectly upregulates FOXP3 expression by inhibiting the ubiquitination of p53, an upstream regulator of miR-149-3p, thereby enhancing the immunosuppressive activity of Tregs (Xu et al., 2021). Here, TP53 is linked to esophageal squamous cell carcinoma.