CD274 and Familial prostate cancer: Similarly, the lncRNA KCNQ1OT1 regulates PD-L1 by sponging miR-15a in prostate cancer and miR-506 in hepatocellular carcinoma (Chen et al., 2020; Zhang et al., 2020), and it also affects the miR-30a/USP22 axis in colorectal cancer, which has implications in cancer progression though direct regulation of PD-L1 protein stability via this specific axis requires further clarification (Xian et al., 2021).