Conversely, shortening the hinge length is a useful method to attenuate the activation of a CAR targeting a membrane-proximal epitope of an overexpressed but not cancer-specific antigen, such as epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), or prostate stem cell antigen (PSCA) (84, 85). Here, ERBB2 is linked to cancer.