On the contrary, immature neutrophils (CD10- CD16-), PMN-MDSC, PD-L1+ M-MDSC, and PD-L1+ e-MDSC, pDC expressing ICOS-L, CD86, or CD40 as well as CD16- NK cell proportions with limited antitumoral potential dominated in tumor tissues. The gene discussed is ICOSLG; the disease is neoplasm.