In our study, tumor-infiltrated T cell populations most probably represented a mixture of activated T cells, effector memory T cells, and potentially exhausted T cells, due to either CD45RA- CCR7- (TTM/TEM) or CD27+, CD28+, ICOS+ and/or 4-1BB+, OX40+, PD-1+ and/or LAG-3+ or CD69+ phenotypes lacking TIM-3 and CTLA-4 expression. The gene discussed is ICOS; the disease is neoplasm.