In contrast, low-disseminated cells exhibited significantly lower OX-40 levels (52% MyLa, p<0.005; SeAx 65%, p<0.005) and reduced ERK1/2 activation (61% MyLa, p<0.005; 51% SeAx, p<0.01), indicating a correlation between OX-40 expression, ERK activation, and the extent of tumor cell dissemination. The gene discussed is TNFRSF4; the disease is neoplasm.