Significant inhibition was also observed in CAM intravasation (72.4% in MyLa embryos, p <0.0001; 55.3% in SeAx embryos, p <0.0001; Figure 2C) and metastasis to the liver (60.7% in MyLa embryos, p <0.0001; 73.2% in SeAx embryos, p <0.0001; Figure 2D) and lung (69.4% in MyLa embryos, p <0.0001; 70.1% in SeAx embryos, p <0.0001; Figure 2E) compared to the controls, highlighting the critical role of OX-40 in driving tumor metastasis, suggesting its potential as a therapeutic target for limiting CTCL dissemination. This evidence concerns the gene TNFRSF4 and neoplasm.