In OX-40 knockout CTCL cells, the production of both IL-5 (Figure 6A) and IL-13 (Figure 6C) was significantly reduced compared to that in controls (p <0.0001), highlighting OX-40’s role in regulating the pro-tumor cytokine network in CTCL. The gene discussed is IL13; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.