Moreover, liquid biopsies using eight protein tumor markers (CA125, CA15.3, CEA, CYFRA 21‐1, HE4, NSE, proGRP, and SCCA) could detect lung cancer, NSCLC, and SCLC with 46, 25, and 40% SEN, respectively. This evidence concerns the gene SERPINB3 and non-small cell lung carcinoma.