The five chosen pathways include the AGE‐RAGE signaling pathway in diabetic complications (degree = 24), lipid and atherosclerosis (degree = 23), fluid shear stress and atherosclerosis (degree = 22), non‐alcoholic fatty liver disease (degree = 16), and the IL‐17 signaling pathway (degree = 15). The gene discussed is RENBP; the disease is atherosclerosis.