The patient presented with a liver mass and pulmonary nodules. The patient initially underwent chemo, then hepatic trisegmentectomy. After surgery, the patient enrolled in a CAR T-cell trial, with initial stabilization of clinical status and AFP. However, the patient progressed, so SFRT was offered. SFRT was preferred over whole liver radiation due to the patient’s poor liver function. The tumor involvement in the biliary system was so diffuse, there would be no appreciable benefit from surgery or interventional radiology. Here, AFP is linked to neoplasm.