TGFBR2 and neoplasm: Since TGF-β regulates a feed-forward cycle of tumor growth in bone that favors of osteolysis (77), our bifunctional D10-Fc-TβRII-ED based trap has the advantage that it homes and retains the TβRII-ED with high affinity in the bone matrix where in can function as a constant TGF-β neutralizer.