While KDM6A does not directly upregulate NEUROD1, studies in KDM6A-mutant SCLC GEMMs and cells suggest that other epigenetic modifiers and transcription factors, such as KMT2A and MYC, may interact with KDM6A to increase NEUROD1 expression (111). This evidence concerns the gene NEUROD1 and small cell lung carcinoma.