Another LSD1 inhibitor, T-3775440, was found to reduce NE markers such as CHGA and GRP in SCLC cell lines H1417 and H510A by directly disrupting the interaction between LSD1 and INSM1/GFI1B, leading to the downregulation of ASCL1 expression (91). The gene discussed is ASCL1; the disease is small cell lung carcinoma.