EZH2 and small cell lung carcinoma: Enhancer of Zeste Homolog 2 (EZH2), the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), induces transcriptional silencing through tri-methylation of histone H3 at lysine 27 (H3K27me3), playing a critical role in cisplatin resistance in SCLC (84).