Additionally, the loss of histone acetyltransferases, including CREBBP (also known as CBP) and its paralog EP300 (also known as p300), leads to a reduction in NE-related epithelial markers and a corresponding rise in non-NE markers, such as ZEB1 and VIM, in SCLC GEMM models (118). Here, EP300 is linked to small cell lung carcinoma.